hand
The Italian word for 'hand' is 'mano'. It is a feminine noun in Italian and is used in many of the same contexts as it is in English. For example, 'dare una mano' means 'to give a hand'.
Give me your hand.
This is a direct request often used when someone wants to help another person, like when crossing the street, or when comforting someone.
I took the book by hand.
In this phrase, the speaker is implying that they physically picked up and held the book, emphasizing the use of their hand.
I have never eaten with my hands.
This sentence is self-explanatory - the speaker has not used their hands for eating before, or usually doesn't eat with their hands.